Rezidor Hotel Group is to create a number of hotel jobs in London with the construction of a new venue - the Park Inn London ExCeL.
The property will be located just 200 m west of the main entrance to the ExCeL Exhibition Centre at the Royal Victoria Dock.
Due to be constructed by Galliford Try, the hotel will feature 223 rooms and Rezidor hopes to open the venue in the second quarter of 2013.
Kurt Ritter, president and chief executive officer at Rezidor, said he was "delighted" to announce the new flagship hotel.
"This property will further strengthen the presence and brand awareness of our young and dynamic mid-market brand Park Inn in the UK," he added.
Last month, Rezidor announced that it was to build new hotels in Newcastle and Bournemouth, creating a number of hotel jobs in the cities.
Newcastle's Radisson Blu Hotel is set to include 170 rooms and the Park Inn Bournemouth will feature 172 rooms.